Davy Klaassen scored inside a moment before Depay opened home his first.
The Barcelona forward struck a panenka from the spot for his second and gestured home his third to make it 4-0.
Guus Til and Donyell Malen scored to make it six and secure the Netherlands' fourth success of the mission.
Depay, 27, joins Johan Cruyff and Abe Lenstra as the Netherlands' eighth top goalscorer with 33 objectives.
The Barcelona striker has scored 12 objectives in his beyond 10 games for his nation, having assumed a significant part in the Netherlands' 4-0 success against Montenegro, where he got twice.
Leicester City protector Caglar Soyuncu's shipping off on the stroke of half-time offered the Netherlands the chance to take advantage of, despite the fact that Cengiz Under dealt with a comfort objective for Turkey in stoppage time.
The Dutch are joint-top with Norway on 13 focuses and lead by a critical objective distinction, having scored 16 objectives in six games.
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